Rabies diagnostic management

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  • October 22, 2021
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Navanithakumar Ballakrishnan. Rabies diagnostic management. 30th Veterinary Association of Malaysia (VAM) Congress. 19th-20th October, 2018. Hilton Hotel, Petaling Jaya, Malaysia.(Abstract of e-Poster Presentation).

 

Navanithakumar Ballakrishnan, Sohayati Abd Rahman, Rohaiza Yaha. Veterinary Research Institute, Department of Veterinary Services, 59, Jalan Sultan Azlan Shah, 31400 Ipoh, Perak, Malaysia. Corresponding author: navin060383@gmail.com 


Rabies is a notifiable re-emerging fatal zoonotic disease of mammals, which becomes a global public health threat. Lately, multiple outbreaks in Perlis, Kedah, Penang (2015) and Perak (2017) affected the country’s Rabies free status. Subsequently, Sarawak had its outbreak in July 2017 and has not resolved till this day. Perlis had also redeclared another outbreak in Jun 2018. Therefore, diagnosing Rabies effectively and accurately is important because laboratory results influence the decision of proceeding post-exposure prophylaxis (in human) and the decision on the need to institute elaborate measures for controlling an outbreak. With that aim, Rabies diagnosis/ confirmatory test is carried out in the National Reference Laboratory, Veterinary Research Institute, Ipoh. Direct Fluorescence Antibody Test, which is recommended by both WHO and OIE is used as a confirmatory test for the presence of Rabies virus antigen in a fresh brain sample. Autolysed brain samples will be subjected to RT-PCR for the detection of Rabies virus antigen. Virus isolation is carried out using Rabies Tissue Culture Infection Test in order to initiate with phylogenetic tree analysis and molecular epidemiology of a new outbreak. Thus, efficient case diagnostic management is crucial to ensure accurate and ultra-fast result reporting to the Veterinary Authority during an outbreak (and surveillance). Continuous epidemics in Sarawak warranted the Sarawak Authority to establish Rabies diagnostic laboratory in State Veterinary Diagnostic Laboratory to carry out routine rabies diagnosis. Yet, all positive cases are referred to VRI for confirmatory diagnoses. With that, VRI ensures the timely delivery quality services in the country. 

Categories: 2018
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