The comparison of immune response of Newcastle Disease Virus vaccine in Specific Pathogen Free (SPF) village chickens

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  • October 22, 2021
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Niny Fariza Junoh. The comparison of immune response of Newcastle Disease Virus vaccine in Specific Pathogen Free (SPF) village chickens. 30th Veterinary Association of Malaysia (VAM) Congress. 19th-20th October, 2018. Hilton Hotel, Petaling Jaya, Malaysia.(Abstract of e-Poster Presentation).


Niny Fariza Junoh, Suriani M.N, Goon S.C., Abdul Jabir J., Jamaliah H., Iswadi M.I .  Veterinary Research Institute, Department of Veterinary Services, 59, Jalan Sultan Azlan Shah, 31400 Ipoh, Perak, Malaysia.  Corresponding author: 

Immune response of ND vaccine 1174/08 strain that was developed at Veterinary Research Institute (VRI) was tested. The objective of this study was to compare the immune response of SPF and village chickens to live ND vaccine 1174/18 strain (NDVAC-1174/2008). A total of nine SPF chickens and nine ND antibody negative village chickens which 14 and 20 days old respectively were vaccinated only once orally with a dose of  106.5 / bird. The unvaccinated control group was inoculated with PBS via the same route. Serum samples from all group were collected weekly interval until 49 days of post vaccination (dpv). All serum sample was subjected for ND’s antibody detection by Haemagglutination Inhibition (HI) test. No clinical sign and mortality were observed in vaccinated chickens throughout the trial. The result revealed that SPF chicken has 71.4 % (n=9) of HI titer log2 ≥ 3 with the mean HI titer (log2 ± SD) 3.14 ± 1.78 at 7 dpv and no HI antibody was detected in village chicken at the same dpv. However, village chicken showed 50% (n=9) of HI titer log2 ≥ 3 at 14 dpv with the mean HI titer (log2 ± SD) 3.5 ± 2.27. No ND HI antibody was detected in the unvaccinated group. The results also showed that a single dose vaccination with a live NDVAC-1174/2008 was able to protect SPF and village chicken until 49 dpv with the mean of HI titer (log2 ± SD) 4.33 ± 0.5 and 4.38 ± 1.41 respectively.  

Keywords: Immune response, Newcastle disease, NDVAC-1174/2008, Haemagglutination Inhibition (HI), Village Chicken, SPF Chicken    

Categories: 2018
Tags: Jurnal/Prosiding/Abstrak