Wound healing activity of Spirulina platensis extract on diabetic rats

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  • October 22, 2021
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Nur Aimi Syarina Pauzi. Wound healing activity of Spirulina platensis extract on diabetic rats. 30th Veterinary Association of Malaysia (VAM) Congress. 19th-20th October, 2018. Hilton Hotel, Petaling Jaya, Malaysia.(Abstract of e-Poster Presentation).


1Nur Aimi Syarina Pauzi, 2Sharida Fakurazi, 2Pike See Cheah, 3Arulselvan Palanisamy  1Veterinary Research Institute, Department of Veterinary Services, 59, Jalan Sultan Azlan Shah, 31400 Ipoh, Perak, Malaysia; 2Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, MALAYSIA; 3Muthayammal Centre for Advanced Research  Corresponding author: aimisyarina@yahoo.com 

Diabetes mellitus, which impairs wound healing process, is associated with the increment in pro-inflammatory cytokines at the wound site.S. platensis was reported to possess anti-inflammatory property and enhanced wound healing in rats. Syarina et al. have  demonstrated that S. platensis aqueous extract enhanced proliferation and migration of human dermal fibroblast (HDF) cells on scratch assay when compared to methanolic and ethanolic extracts. Thus, this study was conducted to investigate the effect of S. platensis aqueous extract topical application in accelerating the wound healing in streptozotocin-induced diabetic rats. Full-thickness skin wound was experimentally created by using 8 mm punch biopsy in male Wistar rats. Group 1 (normal rats with wound) and Group 2 (diabetic rats with wound), were left untreated and served as control. Diabetic rats of Group 3 and 4 were topically treated with 100 mg/kg and 200 mg/kg of S. platensis aqueous extract, respectively. Group 5 animals served as the reference standard and treated with allantoin. Extract-treated animals in group 3 and 4 exhibited 78% and 91% of wound contraction on day 14 respectively, compared to diabetic animals which were only at 53%. Significant decreases in pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) level were observed after treatment of S. platensis aqueous extract. Histological examination of group 4 rats showed thicker re-epithelization and granulation tissue. S. platensis improved healing process in diabetic impaired healing and could potentially be developed as a pharmacological agent in clinical settings.  

Keywords:  Spirulina platensis, diabetic rats, wound healing, aqueous extract, pro-inflammatory cytokines. 

Categories: 2018
Tags: Jurnal/Prosiding/Abstrak